Distribution of the Strains of Multidrug-resistant, Extensively Drug-resistant, and Pandrug-resistant Pseudomonas aeruginosa Isolates from Burn Patients
نویسندگان
چکیده
BACKGROUND Pseudomonas aeruginosa is an opportunistic and Gram-negative pathogen that is used as the most important factor in burn wound infections, and due to the rapid acquisition of multidrug resistance (MDR), it causes high mortality rates in these sectors. Thus, diagnosis and assessment of antibiotic resistance patterns are very important in these patients. The aim of this study was to evaluate antibiotic resistance pattern and determining P. aeruginosa MDR. MATERIALS AND METHODS In this study, phenotypic, biochemical, and polymerase chain reaction tests were used to identify P. aeruginosa from 120 wound burn samples that 96 samples were detected to P. aeruginosa species. In the next step, according to the Clinical and Laboratory Standard Institute standard guidelines, antibiogram test was performed by disk diffusion method for amikacin, ciprofloxacin, norfloxacin, gentamicin, cefepime, aztreonam, meropenem, colistin, ceftazidime, and piperacillin-tazobactam antibiotics. Antibiotic data were analyzed by WHONET software; finally, the rate of antibiotic resistance and MDR strains was determined. RESULTS The highest antibiotic resistance belonged to amikacin (94.8%) and norfloxacin (90.6%); in contrast, colistin (8.3%) had the lowest and the MDR strains were MDR (95.8%) and extensively drug resistance (XDR) (87.5%). CONCLUSION In this study, there was MDR with an alarming rate including MDR (95.8%), XDR (87.5%), and pan-drug resistance (0%). As a result, given antibiotics to patients should be controlled by the antibiogram results to avoid increasing MDR strains.
منابع مشابه
Synergistic Effect of Probiotic Bacteria and Antibiotics on Antibiotic-resistant Strains of Pseudomonas Aeruginosa Isolated from Patients with Burn Wounds
Background: Burn infections are one of the leading causes of death in the world. Antibiotic resistance is a major concern among the medical community. In this study, we investigated the effect of common probiotic strains on multidrug-resistant Pseudomonas aeruginosa strains. Methods: Strains of Pseudomonas aeruginosa from burn wounds of patients were isolated. Then pathogens were biochemically ...
متن کاملنقش ژن mexZ در مقاومت به سیپروفلوکساسین در جدایه های سودوموناس آئروژینوزا در استان گیلان
Messadi AA, Lamia T, Kamel B, Salima O, Monia M, Saida BR. Association between antibiotic use and changes in susceptibility patterns of Pseudomonas aeruginosa in an intensive care burn unit: a 5-year study, 2000-2004. Burns :J Int Soc Burn Injuries 2008;34(8):1098-102. Sherertz RJ, Sarubbi FA. A three-year study of nosocomial infections associated with Pseudomonas aeruginosa. J Clin Micr...
متن کاملPrevalence of MDR, XDR and PDR Phenotypes among Pseudomonas aeruginosa Strains Isolated from Hospitalized Patients in Mazandaran Province, Iran
Background and purpose: Pseudomonas aeruginosa is an opportunistic pathogen and the second leading cause of nosocomial infections, especially in the intensive care unit (ICU), and is responsible for high mortality rates. The aim of this study was to determine the pattern of antibiotic susceptibility and prevalence of multiple drug resistance strains of P. aeruginosa isolated from hospitalized p...
متن کاملBactericidal Effects of Essential Oils from Clove, Lavender and Geranium on Multi-Drug Resistant Isolates of Pseudomonas aeruginosa
The inhibitory effects of essential oils including clove, lavender and geranium extracted from Eugenia caryophyllata, Lavandula officinalis and Pelargonium graveolens on multidrug resistant isolates of Pseudomonas aeruginosa were investigated. The main constituents of clove, lavander and geranium oil were eugenol (80-90%), 1,8-cineol (13%) and citronellol (45%) respectively. Clove had the most ...
متن کاملIn vitro Susceptibility of Pseudomonas aeruginosa Isolated from a Burn Center to Silver Sulfadiazine and Silver Nitrate in Shiraz, South of Iran
Background: Pseudomonas aeruginosa, as an etiological agent, has a prominent infection role in serious burned patients. Burned patients usually treated with antiseptic ointments such as silver sulfadiazine (SSD). This study evaluated the effectiveness of 1% SSD and different concentrations of silver nitrate solution (SNS) on resistant isolates of P. aeruginosa. Methods: Three groups of P. aerug...
متن کامل